Diskussion:Pseudocholinesterase

Hallo,

Mivacurium ist eine sogenannte "nicht deploarisierende Muskelrelaxans", bei der (genau wie bei Atracurium) selbst bei Leber-und Niereninsuffizienz noch eine gute Steuerung möglich ist.

Grüße --Michel Sachs 13:13, 2. Jun. 2007 (CEST)

Succinylcholin ist das einzige depolarisierende Muskelrelaxans, das beim Menschen eingesetzt wird. Aber auch Succinylcholin wird über die PCHE abgebaut.

unterproduktion von BuChE als auslöser bzw indikator für plötzlichen kindstot

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome https://www.sciencedirect.com/science/article/pii/S2352396422002225

Methods

In this case-control study we measured BChE activity and total protein in the eluate of 5μL spots punched from the dried blood spots taken at birth as part of the newborn screening program. Results for each of 67 sudden unexpected deaths classified by the coroner (aged 1 week-104 weeks) = Cases, were compared to 10 date of birth - and gender-matched surviving controls (Controls), with five cases reclassified to meet criteria for SIDS, including the criterion of age 3 weeks to 1 year.

Findings

Conditional logistic regression showed that in groups where cases were reported as “SIDS death” there was strong evidence that lower BChE specific activity (BChEsa) was associated with death (OR=0·73 per U/mg, 95% CI 0·60-0·89, P=0·0014), whereas in groups with a “Non-SIDS death” as the case there was no evidence of a linear association between BChEsa and death (OR=1·001 per U/mg, 95% CI 0·89-1·13, P=0·99).

Interpretation

BChEsa, measured in dried blood spots taken 2-3 days after birth, was lower in babies who subsequently died of SIDS compared to surviving controls and other Non-SIDS deaths. We conclude that a previously unidentified cholinergic deficit, identifiable by abnormal -BChEsa, is present at birth in SIDS (nicht signierter Beitrag von 2003:E9:8F44:DB00:1DC6:10:1164:BA76 (Diskussion) 21:23, 12. Mai 2022 (CEST))